Darvay A, Basarab T, McGregor J M, Russell-Jones R
Department of Dermatology, Ealing Hospital, Southall, UK.
Clin Exp Dermatol. 1999 May;24(3):167-9. doi: 10.1046/j.1365-2230.1999.00444.x.
Although pellagra is a recognized complication of isoniazid therapy, the diagnosis may be overlooked or delayed--sometimes with life-threatening consequences. We report a case of isoniazid-induced pellagra which occurred despite pyridoxine supplementation. Drug withdrawal and supplementation with niacin led to a rapid and sustained clinical improvement. The possible mechanisms of isoniazid induced pellagra are discussed.
尽管糙皮病是异烟肼治疗公认的并发症，但诊断可能被忽视或延误，有时会导致危及生命的后果。我们报告一例尽管补充了吡哆醇仍发生异烟肼诱发糙皮病的病例。停药并补充烟酸后临床迅速且持续改善。本文讨论了异烟肼诱发糙皮病的可能机制。
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