糙皮病综述：病因与发病机制探讨，包括异烟肼所致糙皮病。
Pellagra a review exploring causes and mechanisms, including isoniazid-induced pellagra.
机构信息
Ninewells Hospital and Medical School, Dundee, Scotland.
Dermatology Department, College of Medicine, University of Malawi, Blantyre, Malawi.
出版信息
Photodermatol Photoimmunol Photomed. 2021 Mar;37(2):99-104. doi: 10.1111/phpp.12659. Epub 2021 Feb 2.
Pellagra is a clinical syndrome caused by a deficiency of niacin (nicotinic acid) and/or its precursor tryptophan. The cardinal manifestations are 4 D's: dermatitis, diarrhoea, dementia and in worst case death. Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.
糙皮病是由于烟酸（尼克酸）和/或其前体色氨酸缺乏引起的临床综合征。主要表现为 4 个 D：皮炎、腹泻、痴呆，严重情况下可导致死亡。在潜伏性结核较为常见的国家，随着异烟肼预防用药和抗逆转录病毒疗法的广泛应用，糙皮病的发病率有所上升。
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