乙硫异烟胺诱发的糙皮病。
Ethionamide-induced Pellagra.
作者信息
Gupta Yashashree, Shah Ira
机构信息
Pediatric TB Clinic, B J Wadia Hospital for Children, Mumbai 400012, India.
Pediatric TB Clinic, B J Wadia Hospital for Children, Mumbai 400012, India Consultant in Pediatric Infectious Diseases and Pediatric Hepatology, Nanavati Hospital, Mumbai 400056, India
出版信息
J Trop Pediatr. 2015 Aug;61(4):301-3. doi: 10.1093/tropej/fmv021. Epub 2015 Mar 30.
Pellagra is a disorder characterized by dermatitis, diarrhea, dementia and eventually death, resulting from a deficiency of niacin or its precursor tryptophan. Ethionamide (a second-line antituberculosis agent)-induced pellagra is rarely encountered in clinical practice. Prompt diagnosis and treatment with nicotinamide can prevent life-threatening complications. To date, only three cases have been reported. We report a 13-year-old girl presenting with ethionamide-induced pellagra that resolved after the administration of niacin.
糙皮病是一种以皮炎、腹泻、痴呆并最终导致死亡为特征的病症，由烟酸或其前体色氨酸缺乏引起。乙硫异烟胺（一种二线抗结核药物）诱发的糙皮病在临床实践中很少见。及时诊断并用烟酰胺治疗可预防危及生命的并发症。迄今为止，仅报告过3例。我们报告1例13岁女孩，她出现了乙硫异烟胺诱发的糙皮病，在服用烟酸后病情得到缓解。
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