Bofill M, Borthwick N J, Simmonds H A
Dept of Clinical Immunoloy, Royal Free Hospital, London, UK NW3 2QG.
Immunol Today. 1999 Jun;20(6):258-61. doi: 10.1016/s0167-5699(99)01471-1.
The synthesis of ribonucleotides is essential to cell proliferation. Defects in the relevant metabolic pathways have been demonstrated in stimulated T cells from AIDS patients and are associated with lymphocyte necrotic death. Here, Margarita Bofill and colleagues discuss the possibility that an impaired ribonucleotide metabolism might be common to all rapidly dividing cells and thus contribute to other recognized symptoms of HIV-1 infection.
核糖核苷酸的合成对细胞增殖至关重要。在艾滋病患者受刺激的T细胞中已证实相关代谢途径存在缺陷，且与淋巴细胞坏死性死亡有关。在此，玛格丽塔·博菲尔及其同事探讨了核糖核苷酸代谢受损可能在所有快速分裂细胞中都很常见，从而导致HIV - 1感染的其他公认症状的可能性。
