Bürgisser P, Hammann C, Kaufmann D, Battegay M, Rutschmann O T
Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Clin Exp Immunol. 1999 Mar;115(3):458-63. doi: 10.1046/j.1365-2249.1999.00818.x.
The relationship between blood CD8+ T lymphocyte subsets, as defined by CD28 and CD38 expression, and plasma viraemia and CD4+ T cells in HIV-1 infection was investigated. In a cross-sectional study of 46 patients with either no or stable anti-retroviral treatment, there was a strong negative correlation between the percentage of CD8+CD28- and the percentage of CD4+ T cells (r = -0.75, P < 0.0001), and a positive correlation between absolute numbers of CD8+CD28+ and CD4+ T cells (r = 0.56, P < 0.0001). In contrast, the expression of CD38 by CD8+ T lymphocytes correlated primarily with plasma viraemia (e.g. the percentage of CD38+ in CD8bright cells, r = 0.76, P < 0.0001). In the 6 months following triple therapy initiation in 32 subjects, there was a close correlation between changes (delta) in CD8+CD28+ or CD8+CD28- and in CD4+ T cells (e.g. delta % CD8+CD28+ versus delta % CD4+, r = 0.37, P = 0.0002; delta % CD8+CD28- versus delta % CD4+, r = -0.66, P < 0.0001). A marked decline of the number of CD8+ T cells expressing CD38 was also observed. These results suggest the existence of a T cell homeostasis mechanism operating in blood with CD4+ and CD8+CD28+ cells on the one hand, and with CD8+CD28- cells on the other. In addition, the percentage of CD38+ cells in CD8+ cells, generally considered an independent prognostic factor, could merely reflect plasma viral load.
研究了根据CD28和CD38表达所定义的血液CD8 + T淋巴细胞亚群与HIV-1感染中血浆病毒血症及CD4 + T细胞之间的关系。在一项针对46例未接受抗逆转录病毒治疗或接受稳定抗逆转录病毒治疗患者的横断面研究中，CD8 + CD28 -百分比与CD4 + T细胞百分比之间存在强烈的负相关（r = -0.75，P < 0.0001），而CD8 + CD28 +绝对数量与CD4 + T细胞之间存在正相关（r = 0.56，P < 0.0001）。相比之下，CD8 + T淋巴细胞的CD38表达主要与血浆病毒血症相关（例如，CD8bright细胞中CD38 +的百分比，r = 0.76，P < 0.0001）。在32名受试者开始三联疗法后的6个月内，CD8 + CD28 +或CD8 + CD28 -的变化（delta）与CD4 + T细胞的变化之间存在密切相关性（例如，delta % CD8 + CD28 +与delta % CD4 +，r = 0.37，P = 0.0002；delta % CD8 + CD28 -与delta % CD4 +，r = -0.66，P < 0.0001）。还观察到表达CD38的CD8 + T细胞数量显著下降。这些结果表明，一方面血液中存在一种T细胞稳态机制，涉及CD4 +和CD8 + CD28 +细胞，另一方面涉及CD8 + CD28 -细胞。此外，通常被视为独立预后因素的CD捌细胞中CD38 +细胞的百分比可能仅仅反映血浆病毒载量。
