Caffier G, Kössler F, Küchler G
Acta Biol Med Ger. 1976;35(10):1335-40.
The influence of butyric, hexanoic, octanoic, and decanoic acid on the membrane resting potential of isolated frog skeletal muscles were studied and the osmotic effects of n-alkanoic acids tested. 1. n-alkanoic acids cause osmotic effects like impermeable non-electrolytes (sucrose). Therefore, the permeability to alkanoic acids of the resting muscle cell membrane seems to be small. There are no differences between the acids tested. 2. The membrane resting potential is differently affected. Butyric acid in high concentration effects a hyperpolarization of the membrane whereas higher homologues (C6--C10) cause a depolarization. The depolarizing action increases with increasing concentration, exposure, and with the length of the hydrocarbon chain of the alkanoic acids. 3. It is suggested that osmotic effects are the cause for hyperpolarization of the membrane by high concentrations of butyric acid. 4. The depolarizing action of hexanoic, octanoic, and decanoic acid is discussed with regard to alterations induced by alkanoic acids in the membrane permeability and/or in the metabolism of the cells.
研究了丁酸、己酸、辛酸和癸酸对离体青蛙骨骼肌膜静息电位的影响，并测试了正链烷酸的渗透效应。1. 正链烷酸会引起类似不可渗透非电解质（蔗糖）的渗透效应。因此，静息肌细胞膜对链烷酸的通透性似乎很小。所测试的酸之间没有差异。2. 膜静息电位受到不同影响。高浓度丁酸会使膜超极化，而高级同系物（C6 - C10）则会导致去极化。去极化作用随着浓度增加、暴露时间延长以及链烷酸酸烃链长度的增加而增强。3. 有人认为，渗透效应是高浓度丁酸使膜超极化的原因。4. 就链烷酸引起的膜通透性和/或细胞代谢变化，讨论了己酸、辛酸和癸酸的去极化作用。
