Sokurenko E V, Hasty D L, Dykhuizen D E
Dept of Microbiology, University of Washington, Seattle, WA 98195,
Trends Microbiol. 1999 May;7(5):191-5. doi: 10.1016/s0966-842x(99)01493-6.
Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.
致病性适应性突变，即致病适应性突变，是一种在不进行特定毒力因子水平转移的情况下增强细菌毒力的遗传机制。致病适应性进化在单一感染中以及在确定致病物种的种群结构方面可能具有重要意义。
