Pajak A, Guevara I, Kwaśniak M, Dembińska-Kieć A, Grabarczyk E, Słowik A, Szczudlik A
Pracowni Epidemiologii Klinicznej i Badań Populacyjnych, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 1998;55(12):720-3.
There is a growing evidence on the relations between apoprotein E (apo E), in particular apoE4, cardiovascular disease and Alzheimer's disease. However, little is known on the prevalence of apoE in Polish population. The goal of this paper was to assess the frequency of apoE phenotypes and isoforms in the sample of elderly people. Studied group were 90 men and 92 women, residents of Polish rural province (Tarnobrzeg Voivodship) at age 65-78 years. Identification of apoE isoforms was done using the immunoblotting method. The most frequent phenotype was apoE3/3, which was found in 70% of men and 73% of women. Phenotype apoE3/2 was identified in 20% men and 15% women. Both in men and in women phenotypes apoE4/2 and apoE4/3 were more rare-in total 10% and 12% participants, respectively. There was nobody with phenotype apoE4/4. In women there was also nobody with phenotype apoE4/2, but in men phenotype apoE4/2 was found in 4% of participants. No person was found with phenotype apoE2/2. Frequency of homozygotes apoE4/4 was low in studied population and could little contribute to the epidemy of cardiovascular disease and dementia in the elderly. However, the 10% frequency of heterozygotes with isoform apoE4 could have more impact.
越来越多的证据表明载脂蛋白E（apo E），尤其是apoE4，与心血管疾病和阿尔茨海默病之间存在关联。然而，对于波兰人群中apoE的患病率知之甚少。本文的目的是评估老年人群样本中apoE表型和亚型的频率。研究组包括90名男性和92名女性，他们是波兰农村省份（塔尔诺布热格省）的居民，年龄在65 - 78岁之间。使用免疫印迹法对apoE亚型进行鉴定。最常见的表型是apoE3/3，在70%的男性和73%的女性中发现。在20%的男性和15%的女性中鉴定出apoE3/2表型。在男性和女性中，apoE4/2和apoE4/3表型都较为罕见，分别占参与者总数的10%和12%。没有发现apoE4/4表型的人。在女性中也没有发现apoE4/2表型的人，但在男性中，4%的参与者具有apoE4/2表型。没有发现apoE2/2表型的人。在研究人群中，纯合子apoE4/4的频率较低，对老年人心血管疾病和痴呆症的流行贡献不大。然而，具有apoE4亚型的杂合子10%的频率可能有更大影响。
