Minami E, Shibata H, Nunoura Y, Nomoto M, Fukuda T
Central Research Laboratory, Kotaro Pharmaceutical Co. Ltd., Osaka, Japan.
Am J Chin Med. 1999;27(1):107-15. doi: 10.1142/S0192415X99000136.
The anticonvulsant effects of Shitei-To and its components on maximal electroshock seizures and chemical convulsions were examined. Shitei-To significantly prolonged the latency to bicuculline (2.0 mg/kg, s.c.)-induced clonic convulsions. Repeated treatment with Shitei-To also significantly prolonged the latency to strychnine (1.5 mg/kg, i.p.)- and pentylenetetrazol (90 mg/kg, i.p.)-induced clonic convulsions. On the other hand, Shitei-To had no effect on maximal electroshock seizures. Of the components of Shitei-To, Shitei had almost the same effect as Shitei-To against the clonic convulsions induced by the three chemical agents tested. These findings suggest that Shitei-To has anticonvulsant effects.
研究了柴地汤及其成分对最大电休克惊厥和化学惊厥的抗惊厥作用。柴地汤显著延长了荷包牡丹碱（2.0mg/kg，皮下注射）诱导的阵挛性惊厥的潜伏期。重复给予柴地汤也显著延长了士的宁（1.5mg/kg，腹腔注射）和戊四氮（90mg/kg，腹腔注射）诱导的阵挛性惊厥的潜伏期。另一方面，柴地汤对最大电休克惊厥没有影响。在柴地汤的成分中，柴地对三种受试化学试剂诱导的阵挛性惊厥的作用与柴地汤几乎相同。这些发现表明柴地汤具有抗惊厥作用。
