Spinosa H de S, Gorniak S L, Palermo-Neto J, Bernardi M M, Spinosa F R
Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of Sao Paulo, Brazil.
Vet Hum Toxicol. 1994 Feb;36(1):12-4.
Pretreatment of mice with 30 mg xylazine/kg ip protected against convulsions induced by amphetamine, but it intensified pentylenetetrazole- and strychnine-induced seizures. Xylazine pretreatment also protected rats against electroshock-induced convulsions. These findings support a noradrenergic mechanism being involved in the proconvulsant and/or anticonvulsant effects of xylazine.
