Strobel J S, Epstein A E, Bourge R C, Kirklin J K, Kay G N
Department of Medicine, University of Alabama at Birmingham 35294, USA.
J Interv Card Electrophysiol. 1999 Mar;3(1):15-8. doi: 10.1023/a:1009811203861.
The maximum sinus rate during exertion in humans is inversely related to age. However, the sinus rate at rest is quite variable. The intrinsic heart (IHR) following pharmacologic blockade of autonomic tone with propranolol and atropine has been proposed as a test of sinus node function and is related to age by the linear regression equation: IHR = 118.1 - (0.57 x age). Whether this relationship exists for transplanted hearts for which the donor sinus node is denervated has not been determined.
The relationship between the resting heart rate and the age of the donor heart was examined in 103 patients 1 year following orthotopic cardiac transplantation in the absence of rejection or intercurrent illness. Patients receiving beta-blockers, calcium blockers, antiarrhythmic drugs, digitalis, theophylline, or with biopsy evidence of rejection or abnormal coronary arteriograms were excluded from analysis.
The recipient age, left ventricular ejection fraction, pulmonary capillary pressure, cardiac index, donor heart ischemic time and cardiopulmonary bypass time did not correlate with the rate of the resting donor sinus node. The resting heart rate was inversely related to age of the donor heart by the linear regression equation: HR = 112.0 - (046 x age).
The resting rate of the denervated sinus node is related to donor age with a regression equation that is similar, though slightly slower, than that predicted after pharmacologic autonomic blockade.
人类运动时的最大窦性心率与年龄呈负相关。然而，静息时的窦性心率变化很大。有人提出，用普萘洛尔和阿托品对自主神经张力进行药物阻断后的固有心率（IHR）可作为窦房结功能的一项检测指标，且通过线性回归方程与年龄相关：IHR = 118.1 - （0.57×年龄）。对于供体窦房结去神经支配的移植心脏，这种关系是否存在尚未确定。
在103例原位心脏移植术后1年且无排斥反应或并发疾病的患者中，研究供体心脏静息心率与年龄之间的关系。排除接受β受体阻滞剂、钙通道阻滞剂、抗心律失常药物、洋地黄、茶碱治疗的患者，或有排斥反应活检证据或冠状动脉造影异常的患者后进行分析。
受体年龄、左心室射血分数、肺毛细血管压、心脏指数、供体心脏缺血时间和体外循环时间与供体窦房结静息心率均无相关性。静息心率通过线性回归方程与供体心脏年龄呈负相关：HR = 112.0 - （0.46×年龄）。
去神经支配的窦房结静息心率与供体年龄相关，其回归方程与药物自主神经阻断后预测的方程相似，不过稍慢一些。
