Beauchamp M S, Haxby J V, Jennings J E, DeYoe E A
Section on Functional Brain Imaging, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892-1366, USA.
Cereb Cortex. 1999 Apr-May;9(3):257-63. doi: 10.1093/cercor/9.3.257.
Studies of patients with cerebral achromatopsia have suggested that ventral occipitotemporal cortex is important for color perception. We created a functional magnetic resonance imaging (fMRI) version of a clinical test commonly used to assess achromatopsia, the Farnsworth-Munsell 100-Hue test. The test required normal subjects to use color information in the visual stimulus to perform a color sequencing task. A modification of the test requiring ordering by luminance was used as a control task. Subjects were also imaged as they passively viewed colored stimuli. A limited number of areas responded more to chromatic than achromatic stimulation, including primary visual cortex. Most color-selective activity was concentrated in ventral occipitotemporal cortex. Several areas in ventral cortex were identified. The most posterior, located in posterior fusiform gyrus, corresponded to the area activated by passive viewing of colored stimuli. More anterior and medial color-selective areas were located in the collateral sulcus and fusiform gyrus. These more anterior areas were not identified in previous imaging studies which used passive viewing of colored stimuli, and were most active in our study when visual color information was behaviorally relevant, suggesting that attention influences activity in color-selective areas. The fMRI version of the Farnsworth-Munsell test may be useful in the study of achromatopsia.
对脑性全色盲患者的研究表明，枕颞叶腹侧皮质对颜色感知很重要。我们创建了一种功能性磁共振成像（fMRI）版本的临床测试，该测试常用于评估全色盲，即法恩斯沃思-芒塞尔100色调测试。该测试要求正常受试者利用视觉刺激中的颜色信息来执行颜色排序任务。使用一种要求按亮度排序的测试修改版作为对照任务。受试者在被动观看彩色刺激时也进行了成像。少数区域对彩色刺激的反应比对无色刺激的反应更强烈，包括初级视觉皮质。大多数颜色选择性活动集中在枕颞叶腹侧皮质。腹侧皮质中有几个区域被识别出来。最靠后的区域位于梭状回后部，对应于被动观看彩色刺激时激活的区域。更靠前和内侧的颜色选择性区域位于 collateral sulcus 和梭状回。这些更靠前的区域在以前使用被动观看彩色刺激的成像研究中未被识别出来，并且在我们的研究中，当视觉颜色信息与行为相关时最为活跃，这表明注意力会影响颜色选择性区域的活动。法恩斯沃思-芒塞尔测试的fMRI版本可能对全色盲的研究有用。
