Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Nat Commun. 2023 Sep 22;14(1):5931. doi: 10.1038/s41467-023-41584-0.
The inferotemporal cortex supports our supreme object recognition ability. Numerous studies have been conducted to elucidate the functional organization of this brain area, but there are still important questions that remain unanswered, including how this organization differs between humans and non-human primates. Here, we use deep neural networks trained on object categorization to construct a 25-dimensional space of visual features, and systematically measure the spatial organization of feature preference in both male monkey brains and human brains using fMRI. These feature maps allow us to predict the selectivity of a previously unknown region in monkey brains, which is corroborated by additional fMRI and electrophysiology experiments. These maps also enable quantitative analyses of the topographic organization of the temporal lobe, demonstrating the existence of a pair of orthogonal gradients that differ in spatial scale and revealing significant differences in the functional organization of high-level visual areas between monkey and human brains.
颞下回皮层支持着我们卓越的物体识别能力。已有大量研究旨在阐明该脑区的功能组织，但仍有一些重要问题尚未得到解答，包括这种组织在人类和非人类灵长类动物之间有何不同。在这里，我们使用经过物体分类训练的深度神经网络构建了一个 25 维的视觉特征空间，并使用 fMRI 系统地测量了雄性猴子大脑和人类大脑中特征偏好的空间组织。这些特征图谱使我们能够预测猴子大脑中一个先前未知区域的选择性，这一预测得到了额外的 fMRI 和电生理学实验的证实。这些图谱还能够对颞叶的地形组织进行定量分析，表明存在一对在空间尺度上不同的正交梯度，并揭示了猴子和人类大脑中高级视觉区域的功能组织存在显著差异。
