Feder G, Griffiths C, Eldridge S, Spence M
Department of General Practice and Primary Care, St Bartholomew's and the Royal London Hospital Medical School, Queen Mary and Westfield College, London E1 4NS.
BMJ. 1999 Jun 5;318(7197):1522-6. doi: 10.1136/bmj.318.7197.1522.
To determine whether postal prompts to patients who have survived an acute coronary event and to their general practitioners improve secondary prevention of coronary heart disease.
Randomised controlled trial.
52 general practices in east London, 44 of which had received facilitation of local guidelines for coronary heart disease.
328 patients admitted to hospital for myocardial infarction or unstable angina.
Postal prompts sent 2 weeks and 3 months after discharge from hospital. The prompts contained recommendations for lowering the risk of another coronary event, including changes to lifestyle, drug treatment, and making an appointment to discuss these issues with the general practitioner or practice nurse.
Proportion of patients in whom serum cholesterol concentrations were measured; proportion of patients prescribed beta blockers (6 months after discharge); and proportion of patients prescribed cholesterol lowering drugs (1 year after discharge).
Prescribing of beta bockers (odds ratio 1.7, 95% confidence interval 0.8 to 3.0, P>0.05) and cholesterol lowering drugs (1.7, 0. 8 to 3.4, P>0.05) did not differ between intervention and control groups. A higher proportion of patients in the intervention group (64%) than in the control group (38%) had their serum cholesterol concentrations measured (2.9, 1.5 to 5.5, P<0.001). Secondary outcomes were significantly improved for consultations for coronary heart disease, the recording of risk factors, and advice given. There were no significant differences in patients' self reported changes to lifestyle or to the belief that it is possible to modify the risk of another coronary event.
Postal prompts to patients who had had acute coronary events and to their general practitioners in a locality where guidelines for coronary heart disease had been disseminated did not improve prescribing of effective drugs for secondary prevention or self reported changes to lifestyle. The prompts did increase consultation rates related to coronary heart disease and the recording of risk factors in the practices. Effective secondary prevention of coronary heart disease requires more than postal prompts and the dissemination of guidelines.
确定向急性冠状动脉事件幸存者及其全科医生发送邮政提示是否能改善冠心病的二级预防。
随机对照试验。
伦敦东部的52家全科诊所,其中44家已接受冠心病地方指南推广。
328例因心肌梗死或不稳定型心绞痛入院的患者。
出院后2周和3个月发送邮政提示。提示内容包括降低再次发生冠状动脉事件风险的建议,如生活方式改变、药物治疗以及预约与全科医生或执业护士讨论这些问题。
测量血清胆固醇浓度的患者比例;出院6个月后开具β受体阻滞剂的患者比例;出院1年后开具降胆固醇药物的患者比例。
干预组和对照组在开具β受体阻滞剂(比值比1.7,95%置信区间0.8至3.0,P>0.05)和降胆固醇药物(1.7,0.8至3.4,P>0.05)方面无差异。干预组测量血清胆固醇浓度的患者比例(64%)高于对照组(38%)(2.9,1.5至5.5,P<0.001)。冠心病咨询、危险因素记录和所提供建议等次要结果有显著改善。患者自我报告的生活方式改变或认为有可能改变再次发生冠状动脉事件风险的信念方面无显著差异。
在已传播冠心病指南的地区,向急性冠状动脉事件患者及其全科医生发送邮政提示并未改善二级预防有效药物的处方或自我报告的生活方式改变。提示确实提高了与冠心病相关的咨询率以及诊所中危险因素的记录。冠心病的有效二级预防需要的不仅仅是邮政提示和指南传播。