el-Montaser M, Devlin H, Dickinson M R, Sloan P, Lloyd R E
Department of Dental Medicine and Surgery, University Dental Hospital of Manchester, United Kingdom.
Implant Dent. 1999;8(1):79-85. doi: 10.1097/00008505-199901000-00010.
Titanium screws were implanted in rat calvarial defects of identical size using either a laser or bur. The aims of this study were to determine whether the screws were able to osseointegrate in a laser-prepared bone defect and to compare the pattern of bone healing around these screws. The optimal laser settings to produce a 0.7-mm-diameter hole in the rat calvaria were determined. A 0.7-mm-diameter hole was prepared on the left calvaria with the erbium-YAG laser to receive a 1-mm-diameter self-threading titanium screw. Each animal also received a 0.7-mm-diameter hole prepared on the right calvaria with a conventional metal bur, and a 1-mm-diameter self-threading screw implant was placed. Rats were killed humanely either 3 weeks or 3 months after surgery, and the skulls were processed in paraffin wax for histological analysis. Laser-prepared defects: At 3 weeks, the screw was surrounded by vital woven bone. The dura mater was perforated, and cystic change was present in the underlying brain tissue. There was active bone formation adjacent to the screw surface, deposited on a thin zone of necrotic bone. At 3 months, the screws were osseointegrated, and the brain tissue was healed by gliosis. Bur-prepared defects: At 3 weeks, there was extensive remodeling around the prepared defect. The dura mater was intact, and there was no damage to the underlying brain. At 3 months, the screws were successfully osseointegrated with bone adjacent to the screw. Osseointegration of titanium screws can be achieved using an erbium-YAG laser to prepare the implant bed.
使用激光或牙钻将钛螺钉植入大小相同的大鼠颅骨缺损处。本研究的目的是确定螺钉是否能够在激光制备的骨缺损中实现骨整合，并比较这些螺钉周围的骨愈合模式。确定了在大鼠颅骨上制作直径为0.7毫米孔的最佳激光设置。用铒激光在左颅骨上制备一个直径为0.7毫米的孔，以容纳一个直径为1毫米的自攻钛螺钉。每只动物的右颅骨还用传统金属牙钻制备一个直径为0.7毫米的孔，并植入一个直径为1毫米的自攻螺钉。在手术后3周或3个月对大鼠实施安乐死，将颅骨用石蜡包埋进行组织学分析。激光制备的缺损：术后3周，螺钉被活性编织骨包围。硬脑膜穿孔，其下方的脑组织出现囊性改变。在螺钉表面附近有活跃的骨形成，沉积在一层薄的坏死骨区域上。术后3个月，螺钉实现了骨整合，脑组织通过胶质增生愈合。牙钻制备的缺损：术后3周，在制备的缺损周围有广泛的重塑。硬脑膜完整，其下方的脑组织未受损伤。术后3个月，螺钉与邻近的骨成功实现骨整合。使用铒激光制备种植床可实现钛螺钉的骨整合。
