Nishimura A, Ueno S, Niwa S, Osugi Y, Shinoda Y, Mushimoto K, Shirasu R
Graduate School of Dentistry (Oral and Maxillofacial Surgery), Osaka Dental University, Japan.
J Osaka Dent Univ. 1998 Oct;32(2):43-6.
Using monoclonal antibodies, we performed immunohistochemical investigations of the expression of alpha 2, alpha 3 and beta 4 integrin subunits within the squamous epithelial linings of odontogenic cysts. Tissue samples consisted of both follicular cysts and odontogenic keratocysts from 15 patients. It was found that beta 4 integrin was expressed on the basement membrane regardless of the histological type of the cyst. The degree of immunostaining for alpha 2 and alpha 3 integrin expression corresponded to the thickness of the epithelial cyst wall. We found that the thickness of the epithelial lining of odontogenic cysts had a direct correlation with the expression of integrin molecules.
我们使用单克隆抗体对牙源性囊肿鳞状上皮衬里中α2、α3和β4整合素亚基的表达进行了免疫组织化学研究。组织样本包括15例患者的滤泡囊肿和牙源性角化囊肿。结果发现，无论囊肿的组织学类型如何，β4整合素均在基底膜上表达。α2和α3整合素表达的免疫染色程度与上皮囊肿壁的厚度相对应。我们发现牙源性囊肿上皮衬里的厚度与整合素分子的表达直接相关。
