Kimmerle G, Iyatomi A
Sangyo Igaku. 1976 Jul;18(4):375-82. doi: 10.1539/joh1959.18.375.
Male and female rats were exposed to propoxur (2-isopropoxyphenyl-N-methyl-carbamate) aerosol, concentrations averaging 5.7, 18.7 and 31.7 mg/m3 air, for 6 hours daily on five days in a week over a period of 12 weeks. The effects were depressions of plasma by 20 to 30%, and of erythrocyte and brain cholinesterase activities which were caused by the highest air concentration of 31.7 mg/m3. On the basis of the physical, biochemical, phamacokinetic and metabolic behaviors of propoxur, a maximum allowable concentration of 2.5 mg/m3 air is suggested.
将雄性和雌性大鼠暴露于残杀威（2-异丙氧基苯基-N-甲基氨基甲酸酯）气雾剂中，空气浓度平均为5.7、18.7和31.7毫克/立方米，每周五天，每天6小时，持续12周。最高空气浓度31.7毫克/立方米导致血浆降低20%至30%，红细胞和脑胆碱酯酶活性降低。根据残杀威的物理、生化、药代动力学和代谢行为，建议空气最大允许浓度为2.5毫克/立方米。
