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[急性冠状动脉综合征(不稳定型心绞痛和心肌梗死)患者的免疫学特征]

[Immunological characteristics of patients with acute coronary syndrome (unstable angina and myocardial infarction)].

作者信息

Logacheva I V, Leshchinskiĭ L A, Zvorygin I A

出版信息

Klin Med (Mosk). 1999;77(4):23-5.

Abstract

Admission and discharge values of rosette formation, adhesive and phagocytic ability of neutrophils, exercise tests with calculation of the tension index (TI), serum concentrations of IgG, IgA and IgM, circulating immune complexes (CIC) and cardiolipin antibodies (CAB) were studied in 48 males with unstable angina pectoris and acute myocardial infarction. Acute coronary syndrome is shown to be associated with marked immune alterations, primarily, with elevated levels of CIC and CAB, reduced TI. These alterations persisted for 3-5 weeks of the hospital stay and provoked the risk of repeated infarctions and thrombotic complications after relief of clinical symptoms of acute coronary failure.

摘要

对48例不稳定型心绞痛和急性心肌梗死男性患者的玫瑰花结形成、中性粒细胞黏附及吞噬能力、张力指数(TI)计算的运动试验、IgG、IgA和IgM血清浓度、循环免疫复合物(CIC)及心磷脂抗体(CAB)的入院和出院值进行了研究。急性冠状动脉综合征与明显的免疫改变有关,主要是CIC和CAB水平升高、TI降低。这些改变在住院3 - 5周内持续存在,并在急性冠状动脉衰竭临床症状缓解后引发再次梗死和血栓并发症的风险。

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