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急性心肌梗死患者抗心磷脂抗体水平的临床意义：一项区域性研究。

The clinical significance of anticardiolipin antibody levels in patients with acute myocardial infarction: a regional study.

作者信息

Ertaș Faruk, Can Oznur, Acet Halit, Ozbakkaloglu Mert

机构信息

Department of Cardiology, Medicine Faculty, Dicle University, Diyarbakır, Turkey.

Department of Internal Medicine, Tepecik Education and Research Hospital, İzmir, Turkey.

出版信息

Postepy Kardiol Interwencyjnej. 2013;9(4):328-31. doi: 10.5114/pwki.2013.38859. Epub 2013 Nov 18.

DOI:10.5114/pwki.2013.38859
PMID:24570747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3927103/
Abstract

INTRODUCTION

Acute myocardial infarction (AMI) will probably remain the most important cause of death over the next decades. Traditional risk factors of atherosclerosis could not exactly explain the development of acute coronary events such as AMI. Antiphospholipid antibody syndrome is a disorder characterized by the development of arterial and venous thrombosis.

AIM

In this study, we investigated the relations between acute myocardial infarction and anti-phospholipid antibody syndrome in our population representing Aegean Region people characteristics.

MATERIAL AND METHODS

One hundred patients with acute myocardial infarction were consecutively included in the study (group I) and one hundred age and sex matched people with similar risk factors were enrolled in the study as a control group (group II). Anticardiolipin antibody (aCL) IgM and IgG levels were measured in the two groups. Levels of aCL IgG ≥ 48 U/ml and/or aCL IgM ≥ 44 U/ml were accepted as positive and significant.

RESULTS

In patients with acute myocardial infarction, 5 patients (5%) had positive IgM levels and 8 patients (8%) were found to have positive IgG levels. All cases in the control group had negative aCL IgM and IgG antibody levels. These results were accepted as significant for both aCL antibodies between patients and controls (p < 0.001).

CONCLUSIONS

We concluded that aCL antibody levels are also higher in a small proportion of patients with acute myocardial infarction than controls in our region, also, and these results suggest that there may be an immune stimulus in the pathogenesis of acute coronary events.

摘要

引言

在未来几十年里，急性心肌梗死（AMI）可能仍将是最重要的死亡原因。动脉粥样硬化的传统危险因素无法确切解释诸如AMI等急性冠状动脉事件的发生发展。抗磷脂抗体综合征是一种以动脉和静脉血栓形成为特征的疾病。

目的

在本研究中，我们调查了在代表爱琴海地区人群特征的人群中急性心肌梗死与抗磷脂抗体综合征之间的关系。

材料与方法

连续纳入100例急性心肌梗死患者作为研究组（I组），并纳入100例年龄和性别匹配且具有相似危险因素的人作为对照组（II组）。检测两组中抗心磷脂抗体（aCL）IgM和IgG水平。aCL IgG≥48 U/ml和/或aCL IgM≥44 U/ml的水平被视为阳性且具有统计学意义。

结果

在急性心肌梗死患者中，5例（5%）IgM水平呈阳性，8例（8%）IgG水平呈阳性。对照组所有病例的aCL IgM和IgG抗体水平均为阴性。患者与对照组之间这两种aCL抗体的这些结果均被视为具有统计学意义（p<0.001）。

结论

我们得出结论，在我们地区，一小部分急性心肌梗死患者的aCL抗体水平也高于对照组，而且这些结果表明急性冠状动脉事件的发病机制中可能存在免疫刺激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7d8/3927103/5a64826857ec/PWKI-9-21727-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7d8/3927103/5a64826857ec/PWKI-9-21727-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7d8/3927103/5a64826857ec/PWKI-9-21727-g001.jpg

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