Achudume A C, Adepoju A Y, Abu K A, Olanrewaju I G
Department of Bio-Chemistry, Obafemi Awolowo University, ILE-IFE, Nigeria.
Indian J Exp Biol. 1998 Oct;36(10):1020-2.
Interactive effects of gossypol and chloroquine as determined by activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and liver lactate dehydrogenase (LDH), alkaline phosphatase (ALK-pase), glucose-6-phosphatase (G-6-pase) and cholesterol level were investigated in rats. Administration of gossypol for eight weeks, at a concentration of 20 mg per kg body wt. per day with or without chloroquine had no effect on the serum enzymes and glucose-6-phosphatase activities. When chloroquine at a concentration of 5 mg per kg body wt. thrice a week was administered alone, there was a marked decrease in total protein content and ALK-pose activities, while a significant increase in LDH activity was observed. Administration of either gossypol or chloroquine decreased the level of cholesterol. A greater decrease was recorded when both were given together. It is suggested that gossypol can be employed as a male contraceptive among malaria-infected populations.
通过测定大鼠血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、肝乳酸脱氢酶（LDH）、碱性磷酸酶（ALK-pase）、葡萄糖-6-磷酸酶（G-6-pase）活性以及胆固醇水平，研究了棉酚和氯喹的相互作用。以每天每千克体重20毫克的浓度给大鼠服用棉酚八周，无论是否同时服用氯喹，对血清酶和葡萄糖-6-磷酸酶活性均无影响。当以每千克体重5毫克的浓度每周三次单独给予氯喹时，总蛋白含量和碱性磷酸酶活性显著降低，而乳酸脱氢酶活性则显著增加。单独给予棉酚或氯喹均可降低胆固醇水平。两者同时给予时，胆固醇水平下降幅度更大。建议在疟疾感染人群中可将棉酚用作男性避孕药。
