Brown L M, Linet M S, Greenberg R S, Silverman D T, Hayes R B, Swanson G M, Schwartz A G, Schoenberg J B, Pottern L M, Fraumeni J F
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-7244, USA.
Cancer. 1999 Jun 1;85(11):2385-90.
In the U.S., the incidence rate of multiple myeloma is more than twice as high for blacks as for whites, but the etiology of this malignancy is not well understood.
A population-based case-control interview study of 565 subjects (361 white, 204 black) with multiple myeloma and 2104 controls (1150 white, 954 black) living in 3 areas of the U.S. offered the opportunity to explore whether family history, of cancer contributes to the risk of multiple myeloma and explains the racial disparity in risk.
For both races combined, the risk of multiple myeloma was significantly elevated for subjects who reported that a first-degree relative had multiple myeloma (odds ratio [OR] = 3.7, 95% confidence interval [CI] = 1.2-12.0). Increased risk was also associated with a family history of any hematolymphoproliferative (HLP) cancer (OR = 1.7, 95% CI = 1.0-2.8), especially in a sibling (OR = 2.3, 95% CI = 1.1-4.5). The risk associated with familial occurrence of HLP cancer was higher for blacks than for whites, but the difference between the ORs was not statistically significant.
These data are consistent with previous studies that indicate a familial risk of multiple myeloma, but they explain little of the race-related difference in incidence rates.
在美国，黑人多发性骨髓瘤的发病率是白人的两倍多，但这种恶性肿瘤的病因尚不清楚。
一项基于人群的病例对照访谈研究，对居住在美国3个地区的565名多发性骨髓瘤患者（361名白人，204名黑人）和2104名对照者（1150名白人，954名黑人）进行了调查，以探讨癌症家族史是否会增加多发性骨髓瘤的风险，并解释风险的种族差异。
对于两个种族的综合情况，报告一级亲属患有多发性骨髓瘤的受试者患多发性骨髓瘤的风险显著升高（比值比[OR]=3.7，95%置信区间[CI]=1.2-12.0）。任何血液淋巴增殖性（HLP）癌症的家族史也与风险增加相关（OR=1.7，95%CI=1.0-2.8），尤其是在兄弟姐妹中（OR=2.3，95%CI=1.1-4.5）。黑人中HLP癌症家族性发病相关的风险高于白人，但OR值之间的差异无统计学意义。
这些数据与之前表明多发性骨髓瘤存在家族风险的研究一致，但它们对发病率的种族相关差异解释甚少。
