Osuga Y, Tsutsumi O, Okagaki R, Takai Y, Fujimoto A, Suenaga A, Maruyama M, Momoeda M, Yano T, Taketani Y
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, Japan.
Hum Reprod. 1999 Jun;14(6):1611-3. doi: 10.1093/humrep/14.6.1611.
The concentrations of hepatocyte growth factor (HGF) in peritoneal fluid (PF) from women with endometriosis (n = 36) and without endometriosis (n = 40) were measured. All of the PF samples examined contained detectable concentrations of HGF. The HGF concentrations in PF from women with stage III/IV endometriosis (0.906 ng/ml, 0. 561-1.185; median, interquartile range) were significantly higher (P < 0.0001) than those from women without endometriosis (0.315 ng/ml, 0.251-0.472). The HGF concentrations from women with stage I/II endometriosis (0.417 ng/ml, 0.310-1.023) appeared to be intermediate. There were no apparent variations detected among the HGF concentrations in women in the follicular or luteal phases regardless of the presence of endometriosis. Interestingly, HGF concentrations in PF from women on gonadotrophin releasing hormone analogues, independent of the presence of endometriosis, were comparable with those from untreated women. Given the known mitogenic property of HGF in human endometrial cells, these results suggest that HGF might play a role in the progression of endometriosis.
测量了患有子宫内膜异位症的女性（n = 36）和未患子宫内膜异位症的女性（n = 40）腹腔液（PF）中肝细胞生长因子（HGF）的浓度。所有检测的PF样本均含有可检测浓度的HGF。III/IV期子宫内膜异位症女性的PF中HGF浓度（0.906 ng/ml，0.561 - 1.185；中位数，四分位间距）显著高于未患子宫内膜异位症的女性（0.315 ng/ml，0.251 - 0.472）（P < 0.0001）。I/II期子宫内膜异位症女性的HGF浓度（0.417 ng/ml，0.310 - 1.023）似乎处于中间水平。无论是否存在子宫内膜异位症，卵泡期或黄体期女性的HGF浓度之间均未检测到明显差异。有趣的是，使用促性腺激素释放激素类似物的女性PF中的HGF浓度，无论是否存在子宫内膜异位症，均与未治疗女性的相当。鉴于HGF在人子宫内膜细胞中已知的促有丝分裂特性，这些结果表明HGF可能在子宫内膜异位症的进展中起作用。
