Gazvani M R, Christmas S, Quenby S, Kirwan J, Johnson P M, Kingsland C R
Liverpool Women's Hospital, UK.
Hum Reprod. 1998 Jul;13(7):1957-61. doi: 10.1093/humrep/13.7.1957.
There is increasing evidence that immunological mechanisms play a role in the pathogenesis and pathophysiology of endometriosis. It was therefore of interest to study interleukin-8 (IL-8), a chemokine, in the peritoneal fluid and peripheral blood of women undergoing laparoscopic procedures. The presence and concentrations of IL-8 in relation to endometriosis, infertility and abdominal pain were evaluated. Samples of peritoneal fluid (n = 49) and peripheral blood (n = 50) were obtained from 50 consecutive patients undergoing laparoscopic surgery for various gynaecological indications (abdominal pain, infertility, sterilization). IL-8 was present in the peritoneal fluid of most women (87%). The concentration of IL-8 in the peritoneal fluid was higher in women with endometriosis compared to women without (P = 0.02). This difference was more pronounced in early (stage 1) endometriosis (P = 0.001). IL-8 concentrations in the peritoneal fluid were also higher in women with early endometriosis compared to women with later stages of the disease (P = 0.003). Peripheral blood concentrations did not correlate with peritoneal fluid concentrations of IL-8 and/or the presence of endometriosis. We conclude that IL-8 is an important factor that may contribute to the pathogenesis of endometriosis possibly by promoting neovascularization. This information can be a guide in the development of new therapeutic approaches for the treatment of endometriosis.
越来越多的证据表明，免疫机制在子宫内膜异位症的发病机制和病理生理学中发挥作用。因此，研究白细胞介素-8（IL-8）这一趋化因子在接受腹腔镜手术的女性的腹腔液和外周血中的情况很有意义。评估了IL-8的存在及其浓度与子宫内膜异位症、不孕和腹痛的关系。从50例因各种妇科指征（腹痛、不孕、绝育）接受腹腔镜手术的连续患者中获取腹腔液样本（n = 49）和外周血样本（n = 50）。大多数女性（87%）的腹腔液中存在IL-8。与无子宫内膜异位症的女性相比，患有子宫内膜异位症的女性腹腔液中IL-8的浓度更高（P = 0.02）。这种差异在早期（1期）子宫内膜异位症中更为明显（P = 0.001）。与疾病后期的女性相比，早期子宫内膜异位症女性的腹腔液中IL-8浓度也更高（P = 0.003）。外周血浓度与腹腔液中IL-8浓度和/或子宫内膜异位症的存在无关。我们得出结论，IL-8可能是一个重要因素，可能通过促进新血管形成而有助于子宫内膜异位症的发病机制。这一信息可为开发治疗子宫内膜异位症的新治疗方法提供指导。
