Burger T, Kelényi G, Kett K, Kutas J, Schmelczer M, Szilágyi K
Acta Med Acad Sci Hung. 1976;33(1):13-24.
The kinetics of 51Cr-tagged platelets was studied in 10 patients with idiopathic thrombocytopenic purpura and in 8 patients with congestive splenomegaly. The surgically removed spleens were examined for their platelet content and for their microscopic structure. In idiopathic thrombocytopenic purpura the life-span of platelets was reduced, the number of platelets washed out from the spleen averaged 4.36 X 10(10)/100 g splenic tissue (intrasplenic platelet reserve). The index platelets per g splenic tissue/platelets per ml whole blood reflecting the tendency of platelets to concentrate in the spleen was 8.06. Microscopically, extensive phagocytosis of platelets by macrophages and a preserved lienal architecture were seen. In the group of congestive splenomegaly the life-span of platelets was not significantly shortened and the intrasplenic platelet reserve agreed with the figure found in idiopathic thrombocytopenic purpura. The spleen was characterized by fibroid degeneration and endothelial hypertrophy causing partial obstruction of the sinusoids. It is concluded that while the intrasplenic platelet reserve is nearly the same in idiopathic thrombocytopenic purpura and congestive splenomegaly, in idiopathic thrombocytopenic purpura hypersequestration while in congestive splenomegaly platelet storage predominates.
对10例特发性血小板减少性紫癜患者和8例充血性脾肿大患者进行了51Cr标记血小板动力学研究。对手术切除的脾脏进行了血小板含量及微观结构检查。特发性血小板减少性紫癜患者血小板寿命缩短，从脾脏洗出的血小板数量平均为4.36×10(10)/100g脾组织（脾内血小板储备）。反映血小板在脾脏中聚集倾向的每克脾组织血小板数/每毫升全血血小板数指标为8.06。显微镜下可见巨噬细胞对血小板的广泛吞噬及脾脏结构保存完好。在充血性脾肿大组，血小板寿命无明显缩短，脾内血小板储备与特发性血小板减少性紫癜组的数值一致。脾脏的特点是纤维变性和内皮肥大导致血窦部分阻塞。结论是，虽然特发性血小板减少性紫癜和充血性脾肿大的脾内血小板储备几乎相同，但在特发性血小板减少性紫癜中是脾内扣押过多，而在充血性脾肿大中则以血小板储存为主。
