Chaloupka J, Hlúbik P, Opltová L, Malá H
Vojenská lékarská akademie, Fakultní nemocnice, Hradec Králové.
Sb Lek. 1998;99(3):251-4.
The frequency analysis (fast Fourier transformation) of heart rate variability follow-up during modified orthostatic test is the non-invasive method used to the evaluation of vegetative nervous system (NS) activity. There are only few data about the changes of the parameters in the groups with civilization diseases or with the presence of the risk factors of coronary heart disease. In the groups of 82 volunteers (BMI 24.9 +/- 2.7 kg/m2) and 37 healthy obese people (BMI 36.1 +/- 4.9 kg/m2) we compare some of the vegetative NS parameters. In 16 volunteers we measured the vegetative NS activity changes during the weight reduction regimen (10 day's hospitalization, daily energy intake 3300 kJ, weight before 101.5 +/- 18.1 kg, after 97.5 +/- 17.1 kg, p < 0.0001). Acute reactions to the energy restriction were evaluated in 3 groups of 10 volunteers during 3 days of the energy intake 3200, 6600 and 13400 kJ. Obese persons show a slight decrease of both sympathetic and parasympathetic NS activity. In the supine position only few changes in the sympathetic/parasympathetic NS activity ration were observed. In the standing position in obese group drop of the most indexes and decrease of sympathetic/parasympathetic NS activity ratio were described. Significant correlations between sympathetic NS activity and lipid oxidation (r = 0.329, p < 0.01) as well as saccharide oxidation (r = -0.258, p < 0.05) were observed. During the weight reduction slight increase of the parasympathetic NS activity and higher one in the sympathetic NS activity were measured. The values after weight reduction regime are comparable with the control group of the lean persons. Different changes of the parameters were described in standing and in supine position. Acute reaction on the low-energy diet was observed in a few days. It shows a slight increase of the NS activity parameters. Relative increase mainly in the sympathetic nervous system activity doesn't depend on the degree of energy deficit only, but some subjective factors may play a role (age, psychological and psychosocial factors, agreeability of the diet, behavioral factors ...). In the group of obese persons non-specific changes of the vegetative NS activity were observed. They are modulated by some behavioral factors. The tendency to the higher parasympathetic NS activity confirms the MONA LISA theory of the origin of obesity. Important are the informations of the return of the indexes after overweight reduction.
改良直立试验期间心率变异性随访的频率分析（快速傅里叶变换）是用于评估自主神经系统（NS）活动的非侵入性方法。关于患有文明病或存在冠心病危险因素的人群中参数变化的数据很少。在82名志愿者组（体重指数24.9±2.7kg/m²）和37名健康肥胖者组（体重指数36.1±4.9kg/m²）中，我们比较了一些自主神经系统参数。在16名志愿者中，我们测量了减肥方案期间（住院10天，每日能量摄入3300kJ，体重减轻前101.5±18.1kg，减轻后97.5±17.1kg，p<0.0001）自主神经系统活动的变化。在3组每组10名志愿者中，在能量摄入3200、6600和13400kJ的3天期间评估了对能量限制的急性反应。肥胖者的交感神经和副交感神经NS活动均略有下降。在仰卧位，交感神经/副交感神经NS活动比值仅观察到很少变化。在肥胖组的站立位，描述了大多数指标下降以及交感神经/副交感神经NS活动比值降低。观察到交感神经NS活动与脂质氧化（r=0.329，p<0.01）以及糖类氧化（r=-0.258，p<0.05）之间存在显著相关性。在减肥期间，测量到副交感神经NS活动略有增加，交感神经NS活动增加更多。减肥方案后的数值与瘦人对照组相当。在站立位和仰卧位描述了参数的不同变化。在几天内观察到对低能量饮食的急性反应。它显示NS活动参数略有增加。主要在交感神经系统活动中的相对增加不仅取决于能量缺乏程度，一些主观因素可能起作用（年龄、心理和社会心理因素、饮食的可接受性、行为因素……）。在肥胖者组中观察到自主神经系统活动的非特异性变化。它们受一些行为因素调节。副交感神经NS活动较高的趋势证实了肥胖起源的MONA LISA理论。超重减轻后指标恢复的信息很重要。
