Quadri R, Maule S, Flecchia D, Veglio M, Rovera L, Rosa C, Zanone M, Fonzo D
Department of Medicine and Experimental Oncology, San Vito Hospital, University of Turin, Italy.
Funct Neurol. 1990 Jul-Sep;5(3):273-6.
The heart rate response to deep breathing (DB test) and standing (30:15 r test) and the blood pressure response to standing (LS test) and sustained handgrip (HG test) were assessed in 19 obese subjects and 15 age matched lean controls. The results of DB, 30:15 r and LS tests were not significantly different in both groups. The diastolic blood pressure increase during handgrip was significantly higher in obese than in control subjects. After a period of caloric restriction the tests were repeated in 9 patients who had obtained a weight loss of at least 5 kg: a significant decrease in heart rate, diastolic blood pressure and 30:15 r results was observed, whereas the caloric restriction did not cause significant variations in the results of DB, LS and HG tests. Our results suggest that in obese patients some autonomic nervous changes can occur before and after weight loss.
对19名肥胖受试者和15名年龄匹配的瘦对照组进行了深呼吸（DB试验）、站立（30:15 r试验）时的心率反应以及站立（LS试验）和持续握力（HG试验）时的血压反应评估。两组的DB、30:15 r和LS试验结果无显著差异。肥胖受试者握力时舒张压升高显著高于对照组。在9名体重减轻至少5 kg的患者进行一段时间的热量限制后重复进行这些试验：观察到心率、舒张压和30:15 r结果显著降低，而热量限制并未使DB、LS和HG试验结果发生显著变化。我们的结果表明，肥胖患者在体重减轻前后可能会出现一些自主神经变化。
