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[血液透析患者的乙型肝炎免疫接种]

[Hepatitis B immunization in hemodialysis patients].

作者信息

Skladaný L, Svác J, Javorský P, Kmet' M

机构信息

Interná klinika B NsP F. D. Foosevelta, Banská Bystrica.

出版信息

Vnitr Lek. 1998 Sep;44(9):535-7.

Abstract

Infection with the virus of hepatitis B is found in haemodialyzed patients many times more frequently than in the normal population and it participates in their morbidity and mortality. It is also an important issue in patients after transplantation of the kidney. With regard to the alarmingly high prevalence of this infection in their haemodialyzation centre the authors analyzed retrospectively the effectiveness of the most successful preventive measure--active immunization--in 84 patients immunized with Engerix B according to the protocol recommended for haemodialyses. They found that: i) active immunization started after the onset of haemodialyzation has a low effectiveness and in patients who do lack protective antibodies anti-HBs before the onset of haemodialysis it is important to look for other preventive measures; ii) a certain effectiveness is achieved only by administration of more than three doses of vaccine.

摘要

在接受血液透析的患者中,乙肝病毒感染的发生率比正常人群高许多倍,且它与患者的发病和死亡有关。在肾移植患者中,这也是一个重要问题。鉴于其血液透析中心这种感染的患病率高得惊人,作者回顾性分析了最成功的预防措施——主动免疫——在84例按照血液透析推荐方案用安在时(Engerix B)免疫的患者中的效果。他们发现:i)血液透析开始后才开始的主动免疫效果不佳,对于在血液透析开始前缺乏保护性抗体抗-HBs的患者,寻找其他预防措施很重要;ii)只有接种超过三剂疫苗才能取得一定效果。

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