Gibson E S, Lesiak K, Watanabe K A, Gudas L J, Pankiewicz K W
Graduate School of Medical Sciences, Department of Pharmacology, Cornell University, New York, NY 10021, USA.
Nucleosides Nucleotides. 1999 Mar;18(3):363-76. doi: 10.1080/15257779908043082.
A synthesis of the C-nucleoside, 2-amino-7-(2-deoxy-beta-D-erythro- pentofuranosyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one (9-deaza-2'-deoxyguanosine) was achieved starting from 2-amino-6-methyl-3H-pyrimidin-4-one (5) and methyl 2-deoxy-3,5-di-O-(p-nitrobenzoyl)-D-erythro-pento-furanoside (11). The anomeric configuration of the C-nucleoside was established by 1H NMR, NOEDS and ROESY. This C-nucleoside did not inhibit the growth of T-cell lymphoma cells.
