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使用 Heck 方法合成 2'-脱氧-9-去氮核苷。

Synthesis of 2'-deoxy-9-deaza nucleosides using Heck methodology.

机构信息

University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, United States.

出版信息

J Org Chem. 2013 Jul 19;78(14):7305-11. doi: 10.1021/jo400913k. Epub 2013 Jul 5.

DOI:10.1021/jo400913k
PMID:23806030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5638437/
Abstract

During the synthesis of a series of 2'-deoxy-9-deaza nucleosides using Heck methodology, the necessity for a pyrrole protecting group was discovered. The results of this brief study revealed that the benzyloxymethyl (BOM) group proved optimal, and Heck coupling using Jeffery conditions increased the coupling yield significantly. The results are reported herein.

摘要

在使用 Heck 方法合成一系列 2'-脱氧-9-脱氮核苷时，发现需要使用吡咯保护基。这项简短研究的结果表明，苄氧甲基（BOM）基团是最佳选择，并且使用 Jeffery 条件进行 Heck 偶联可以显著提高偶联产率。现将结果报告如下。

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