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拓展核酸催化剂的催化功能：同时掺入两种带有铵基和咪唑基官能团的修饰脱氧核糖核苷三磷酸。

Expanding the catalytic repertoire of nucleic acid catalysts: simultaneous incorporation of two modified deoxyribonucleoside triphosphates bearing ammonium and imidazolyl functionalities.

作者信息

Perrin D M, Garestier T, Hélène C

机构信息

Laboratoire de Biophysique, Museum National d'Histoire Naturelle, Paris, France.

出版信息

Nucleosides Nucleotides. 1999 Mar;18(3):377-91. doi: 10.1080/15257779908043083.

DOI:10.1080/15257779908043083
PMID:10358942
Abstract

Two nucleoside triphosphates, a pyrimidine modified with an ammonium functionality and a purine modified with an imidazolyl functionality are compatible with all conditions for a combinatorial selection of nucleic-acid catalysts. We believe that this work is the first to demonstrate the potential for using not one but two modified nucleotides in tandem. The potential for an enriched catalytic repertoire is envisioned.

摘要

两种核苷三磷酸，一种用铵官能团修饰的嘧啶和一种用咪唑基官能团修饰的嘌呤，与核酸催化剂组合筛选的所有条件均兼容。我们认为这项工作首次证明了串联使用两种而非一种修饰核苷酸的潜力。人们设想了丰富催化库的潜力。

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