Iwabuchi S, Bishara S, Herbison P, Erasmus A, Samejima H
Department of Neurosurgery, Dunedin Hospital, New Zealand.
Neurol Med Chir (Tokyo). 1999 Apr;39(4):273-9; discussion 279-81. doi: 10.2176/nmc.39.273.
The principal prognostic factors and effect on survival were retrospectively evaluated in 56 adult patients with supratentorial low grade astrocytomas treated between 1967 and 1993. Fifteen factors were evaluated with uni- and multivariate analysis to investigate their importance in predicting the length of survival. The median patient age at presentation was 42 years and the median survival was 5.0 years. The following characteristics were associated with improved patient survival by univariate analysis (p < 0.01): Age group, preoperative Karnofsky scale, and extent of surgery. Age group and Karnofsky scale were significant by multivariate analysis, but not the extent of surgery. Thus the usefulness of cytoreductive surgery in the management remains unclear, but the extent of surgery is determined by the characteristics of the tumor and the potential of the patient. Since 93% of our patients received postoperative radiotherapy, the effect of adjuvant irradiation could not be determined.
对1967年至1993年间接受治疗的56例幕上低级别星形细胞瘤成年患者的主要预后因素及其对生存的影响进行了回顾性评估。通过单因素和多因素分析评估了15个因素，以研究它们在预测生存时长方面的重要性。患者就诊时的中位年龄为42岁，中位生存期为5.0年。单因素分析显示，以下特征与患者生存改善相关（p < 0.01）：年龄组、术前卡氏评分以及手术范围。多因素分析表明年龄组和卡氏评分具有显著性，但手术范围并非如此。因此，减瘤手术在治疗中的作用仍不明确，但手术范围由肿瘤特征和患者潜力决定。由于93%的患者接受了术后放疗，辅助放疗的效果无法确定。
