Nicolato A, Gerosa M A, Fina P, Iuzzolino P, Giorgiutti F, Bricolo A
Department of Neurosurgery, University Hospital, Verona, Italy.
Surg Neurol. 1995 Sep;44(3):208-21; discussion 221-3. doi: 10.1016/0090-3019(95)00184-0.
A retrospective uni-multivariate statistical analysis was performed on 32 prognostic factors to investigate their importance in predicting survival in a series of 76 adult patients with low-grade supratentorial astrocytomas treated over a 13-year period. The end point used for this study was the length of survival. The median survival time was 40 months. Overall actuarial survival at 2, 5, and 10 years was 69%, 38%, and 22%, respectively. Radical resection of the neoformation, a higher preoperative Karnofsky performance status (KPS) score, and an age younger than 50 years are strongly correlated with survival; postoperative radiotherapy appears to be associated with increased survival only in patients under 50 years of age.
对32个预后因素进行了回顾性单变量和多变量统计分析，以研究它们在预测76例成人幕上低级别星形细胞瘤患者生存情况中的重要性。这些患者在13年期间接受了治疗。本研究使用的终点是生存时长。中位生存时间为40个月。2年、5年和10年的总体精算生存率分别为69%、38%和22%。肿瘤的根治性切除、术前较高的卡诺夫斯基功能状态（KPS）评分以及年龄小于50岁与生存密切相关；术后放疗似乎仅在50岁以下的患者中与生存率提高有关。
