Pinchuk I, Lichtenberg D
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
FEBS Lett. 1999 May 7;450(3):186-90. doi: 10.1016/s0014-5793(99)00488-3.
Excessive uptake of oxidized low density lipoprotein plays a role in the onset of atherosclerosis. Lipid-associated antioxidants, the most abundant of which is tocopherol (vitamin E), are therefore believed to have anti-atherogenic properties. By contrast, hydroperoxides enhance the peroxidation of low density lipoprotein. We demonstrate that none of these compounds markedly affect the maximal rate of oxidation of low density lipoprotein, whereas the lag preceding rapid oxidation is prolonged by tocopherol but shortened by hydroperoxides. The corresponding 'prolongation' and 'shortening' can be compensated by each other in low density lipoprotein preparations enriched with both these compounds. The dependence of the balance between the effects of tocopherol and hydroperoxides on the copper concentration indicates that the antioxidative effect of vitamin E increases with the oxidative stress.
氧化型低密度脂蛋白的过度摄取在动脉粥样硬化的发病过程中起作用。因此，与脂质相关的抗氧化剂（其中最丰富的是生育酚（维生素E））被认为具有抗动脉粥样硬化特性。相比之下，氢过氧化物会增强低密度脂蛋白的过氧化作用。我们证明，这些化合物均未显著影响低密度脂蛋白的最大氧化速率，而生育酚可延长快速氧化之前的延迟期，而氢过氧化物则会缩短该延迟期。在同时富含这两种化合物的低密度脂蛋白制剂中，相应的“延长”和“缩短”可以相互补偿。生育酚和氢过氧化物的作用之间的平衡对铜浓度的依赖性表明，维生素E的抗氧化作用随氧化应激而增加。
