Sinsel N K, Guelinckx P J, Opdebeeck H
Department of Plastic and Reconstructive Surgery, Catholic University of Leuven, Belgium.
Plast Reconstr Surg. 1999 Jun;103(7):1887-92. doi: 10.1097/00006534-199906000-00013.
In a previous study in the rabbit, it was demonstrated that paralysis of the midfacial musculature results in decreased anteroposterior growth of the snout. At the end of growth, these animals showed macroscopically striking similarities to animals with unilateral fusion of the nasofrontal suture. In this study, whether nasofrontal sutural growth is unilaterally restricted in animals with unilateral partial facial paralysis was investigated. A left-sided partial facial paralysis was induced in sixteen 12-day-old New Zealand White rabbits. At the ages of 5, 9, 12, and 17 weeks, four animals were randomly assigned to be killed for analysis of nasofrontal sutural growth. In each animal, the left experimental side was compared with the right control side. By means of histomorphometric measurements, it was shown that diminished sutural growth activity was present on the left paralyzed side in periods of rapid growth. On the other hand, no significant alterations in sutural width were found. These findings seem to explain some of the macroscopic growth alterations (i.e., diminished anterior maxillary length) observed in rabbits with unilateral partial facial paralysis.
在之前一项针对兔子的研究中，已证实面中部肌肉组织麻痹会导致口鼻部前后生长减少。在生长结束时，这些动物在宏观上与鼻额缝单侧融合的动物表现出惊人的相似性。在本研究中，调查了单侧部分面神经麻痹的动物鼻额缝生长是否受到单侧限制。在16只12日龄的新西兰白兔中诱导左侧部分面神经麻痹。在5、9、12和17周龄时，随机挑选4只动物处死，以分析鼻额缝生长情况。在每只动物中，将左侧实验侧与右侧对照侧进行比较。通过组织形态计量学测量表明，在快速生长阶段，左侧麻痹侧的缝生长活性降低。另一方面，未发现缝宽度有明显改变。这些发现似乎解释了单侧部分面神经麻痹兔所观察到的一些宏观生长改变（即上颌前部长度减少）。
