Department of Orthodontics, School of Dentistry, University of Washington, Seattle, WA 98195, USA.
Am J Orthod Dentofacial Orthop. 2013 Jun;143(6):773-83. doi: 10.1016/j.ajodo.2013.01.012.
The nasal septum is thought to be a primary growth cartilage for the midface and, as such, has been implicated in syndromes involving midfacial hypoplasia. However, this internal structure is difficult to study directly. The aims of this study were to provide direct, continuous measurements of the growth of the nasal septal cartilage and to compare these with similar measurements of the nasofrontal suture to test whether the growth of the cartilage precedes the growth of the suture and whether the growth of the septal cartilage is constant or episodic.
Ten Hanford minipigs were used. Linear displacement transducers were implanted surgically in the septal cartilage and across the nasofrontal suture. Length measurements of the cartilage and suture were recorded telemetrically each minute for several days.
The growth rate of the nasal septal cartilage (0.07% ± 0.03% length/h) was significantly higher than that of the suture (0.03% ± 0.02% length/h) (P = 0.004). The growth of both structures was episodic with alternating periods of growth (5-6 per day) and periods of stasis or shrinkage. No diurnal variation in growth of the cartilage was detected.
These results are consistent with the notion that growth of the septal cartilage might drive growth of the nasofrontal suture. Growth of the midface is episodic rather than constant.
鼻中隔被认为是中面部的主要生长软骨，因此与涉及中面部发育不全的综合征有关。然而，这种内部结构很难直接研究。本研究的目的是提供鼻中隔软骨生长的直接、连续测量，并将其与类似的鼻额缝测量进行比较，以测试软骨的生长是否先于缝的生长，以及软骨的生长是连续的还是间歇性的。
使用 10 只汉福德小型猪。线性位移传感器通过手术植入鼻中隔软骨和鼻额缝。每隔一分钟通过遥测记录软骨和缝线的长度测量值，持续几天。
鼻中隔软骨的生长速度（0.07%±0.03%长度/小时）明显高于缝（0.03%±0.02%长度/小时）（P=0.004）。这两种结构的生长都是间歇性的，交替出现生长（每天 5-6 次）和停滞或收缩期。未检测到软骨生长的昼夜变化。
这些结果与鼻中隔软骨的生长可能驱动鼻额缝生长的观点一致。中面部的生长是间歇性的，而不是连续的。
