Barondes S H
Department of Psychiatry, Center for Neurobiology and Psychiatry, University of California-San Francisco 94143-0984, USA.
Arch Gen Psychiatry. 1999 Jun;56(6):549-52. doi: 10.1001/archpsyc.56.6.549.
Although it has long been known that people inherit vulnerabilities to particular forms of mental illness, ongoing advances in psychiatric genetics and DNA technology are only now making it possible to actually find the specific genes and gene variants that play critical roles in complex disorders, such as schizophrenia and bipolar disorder. For this reason, the National Institute of Mental Health convened a work group "to facilitate the search for the genes that influence mental disorders"--genes whose identification will affect diagnosis, prevention, and treatment. This article briefly summarizes the problems addressed by the work group and its main recommendations.
尽管人们早就知道,某些特定形式的精神疾病的易感性是可遗传的,但直到现在,随着精神病遗传学和DNA技术的不断进步,才使得实际找到在诸如精神分裂症和双相情感障碍等复杂疾病中起关键作用的特定基因和基因变体成为可能。因此,美国国立精神卫生研究所召集了一个工作组,“以促进对影响精神障碍的基因的寻找”——这些基因的识别将影响诊断、预防和治疗。本文简要总结了该工作组所解决的问题及其主要建议。