Ashman S B, Monk T H, Kupfer D J, Clark C H, Myers F S, Frank E
Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD, USA.
Psychiatry Res. 1999 Apr 19;86(1):1-8. doi: 10.1016/s0165-1781(99)00019-0.
Disruptions in the sleep-wake cycle frequently characterize affective illness and have led to a number of theories linking sleep-wake and/or circadian rhythm disturbance to affective illness. Recently, researchers have expanded these chronobiological theories to include the role of lifestyle regularity, or daily social rhythms. In this study, the Social Rhythm Metric (SRM) was used to explore the relationship between social rhythms and mood in patients with rapid cycling bipolar disorder and to compare the social rhythms of patients with those of healthy control subjects. Patients' SRM scores and activity level indices were significantly lower than those of control subjects. In addition, the timing of five, mostly morning, activities was phase delayed in patients compared to control subjects. Patients also demonstrated a phase delay in the timing of morning activities during depression compared to hypomania or euthymia. The phase changes in the timing of morning activities are consistent with other data implicating morning zeitgebers in the pathophysiology of rapid cycling bipolar disorder.
睡眠-觉醒周期的紊乱常常是情感性疾病的特征，并引发了许多将睡眠-觉醒和/或昼夜节律紊乱与情感性疾病联系起来的理论。最近，研究人员将这些生物钟学理论进行了扩展，将生活方式规律或日常社交节律的作用纳入其中。在本研究中，社交节律指标（SRM）被用于探究快速循环型双相情感障碍患者的社交节律与情绪之间的关系，并将患者的社交节律与健康对照者的进行比较。患者的SRM得分和活动水平指数显著低于对照者。此外，与对照者相比，患者五项主要在早晨进行的活动的时间出现了相位延迟。与轻躁狂或心境正常期相比，患者在抑郁期早晨活动时间也表现出相位延迟。早晨活动时间的相位变化与其他表明早晨同步信号参与快速循环型双相情感障碍病理生理学的数据一致。
