Cáceres A, Taleisnik S
Neuroendocrinology. 1976;22(1):30-7. doi: 10.1159/000122609.
The effect of electrochemical stimulation (anodic current, 100 micronA/30 sec) of thalamic nuclei was studied in nonanesthetized freely-behaving rats bearing chronic implanted electrodes and plastic cannulae inserted into the jugular vein for blood sampling. Stimulation of the anterior thalamic nuclei, the nucleus (n.) mediodorsalis thalami (MD) and the n. posteromedianus thalami at 2 p.m. on the day of proestrus prevented spontaneous ovulation and the release of LH which takes place on that day. No effect on ovulation or LH release was observed after stimulation of the n. lateralis thalami, the n. ventralis thalami or other thalamic nuclei or after passing a cathodic current through the n. MD. Stimulation of the n. MD resulted also in a significant decrease of the elevated serum LH levels found after an injection of progesterone into ovariectomyzed estrogen-primed rats. These results indicate that nuclei of the medial thalamic region are capable of inhibiting LH secretion. No stimulatory influence of LH release was observed after thalamic stimulation in ovariectomized estrogen-treated rats.
在植入慢性电极且经颈静脉插入塑料套管用于采血的未麻醉自由活动大鼠中，研究了丘脑核团的电化学刺激（阳极电流，100微安/30秒）的作用。在动情前期当天下午2点刺激丘脑前核、丘脑背内侧核（MD）和丘脑后内侧核，可阻止自发排卵以及当天发生的促黄体生成素（LH）释放。刺激丘脑外侧核、丘脑腹侧核或其他丘脑核团，或通过阴极电流刺激MD核后，未观察到对排卵或LH释放有影响。刺激MD核还导致在给切除卵巢并用雌激素预处理的大鼠注射孕酮后所发现的血清LH水平升高显著降低。这些结果表明，丘脑内侧区域的核团能够抑制LH分泌。在切除卵巢并用雌激素处理的大鼠中，丘脑刺激后未观察到对LH释放有刺激作用。
