组合合成设计

Combinatorial synthetic design.

作者信息

Oliver S F, Abell C

机构信息

University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.

出版信息

Curr Opin Chem Biol. 1999 Jun;3(3):299-306. doi: 10.1016/S1367-5931(99)80046-5.

DOI:10.1016/S1367-5931(99)80046-5

PMID:10359710

Abstract

The range and diversity of solid-phase synthetic methodology continues to develop very rapidly, allowing the generation of previously inaccessible compound libraries. The design of such libraries requires consideration of linkage strategies, newly developed solid-phase reactions and emerging solution-phase processes.

摘要

固相合成方法的范围和多样性仍在迅速发展，使得以前难以获得的化合物库得以生成。此类库的设计需要考虑连接策略、新开发的固相反应和新兴的溶液相过程。