Tan Derek S
Tri-Institutional Research Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 422, New York, New York 10021, USA.
Nat Chem Biol. 2005 Jul;1(2):74-84. doi: 10.1038/nchembio0705-74.
Diversity-oriented synthesis (DOS) is an emerging field involving the synthesis of combinatorial libraries of diverse small molecules for biological screening. Rather than being directed toward a single biological target, DOS libraries can be used to identify new ligands for a variety of targets. Several different strategies for library design have been developed to target the biologically relevant regions of chemical structure space. DOS has provided powerful probes to investigate biological mechanisms and also served as a new driving force for advancing synthetic organic chemistry.
多样性导向合成（DOS）是一个新兴领域，涉及合成用于生物筛选的各种小分子组合文库。与针对单一生物靶点不同，DOS文库可用于识别多种靶点的新配体。已经开发了几种不同的文库设计策略，以针对化学结构空间中与生物学相关的区域。DOS提供了强大的探针来研究生物学机制，也为推动有机合成化学提供了新的动力。
