Fung T Y, Li C Y
J Reprod Med. 1999 May;44(5):475-7.
Pregnancy in women with secondary biliary cirrhosis due to recurrent pyogenic cholangitis is extremely rare. Little information is available on the effect of pregnancy on the disease and vice versa.
A patient who had secondary biliary cirrhosis due to recurrent pyogenic cholangitis complicated by splenomegaly and portal hypertension had a successful pregnancy. Although she had a history of esophageal variceal bleeding before this pregnancy, there was no such bleeding during pregnancy. She had an uneventful antenatal course except that her liver enzyme level fluctuated slightly. The serum bilirubin level increased during the third trimester of pregnancy but returned to the prepregnant level after delivery.
Termination of pregnancy may not be the only option for management. The management protocol for patients with primary biliary cirrhosis complicating pregnancy, which includes regular fetal surveillance and monitoring of maternal liver function, should be considered for pregnant women with secondary biliary cirrhosis.
因复发性化脓性胆管炎导致继发性胆汁性肝硬化的女性怀孕极为罕见。关于怀孕对该疾病的影响以及反之疾病对怀孕的影响,目前所知甚少。
一名因复发性化脓性胆管炎导致继发性胆汁性肝硬化并伴有脾肿大和门静脉高压的患者成功怀孕。尽管她在此次怀孕前有食管静脉曲张出血史,但孕期未发生此类出血。除肝酶水平略有波动外,她的产前过程顺利。孕期第三个月血清胆红素水平升高,但产后恢复到孕前水平。
终止妊娠可能不是唯一的处理方式。对于患有继发性胆汁性肝硬化的孕妇,应考虑采用用于原发性胆汁性肝硬化合并妊娠患者的管理方案,包括定期胎儿监测和母体肝功能监测。