Terada H, Kajiura T, Kyoi K, Utsumi S, Hori H
No To Shinkei. 1976 Feb;28(2):151-6.
Review was made on the effect of adenosine triphosphate, 1.0-3.0 mg/kg intravenously, on the cerebral circulation and the presence of the dilating action on the cerebral blood-vessels in cats. 1. The group of the normal intra-cranial pressure showed, as reported previously, the transient hypotension and its complicated decrease of cerebral blood-circulation at the initial period for 30-100 check, then demonstrating the increase of cerebral blood-flow for 200-1000 check. Its increased volume and duration were dose-dependent. 2. The group of the loaded intracranial pressure of 20-30 mmHg (slightly elevated group) showed the increase of cerebral blood-flow, like the group of the normal intracranial pressure. However, the effect of ATP showed the decrease or disappearance in accordance with the elevation of the loaded pressure. 3. Cerebral vasodilating effect of ATP was promptly observed after the administration, and its degree was 30-50% in photographical observation. 4. Increasing effect on cerebral blood-flow and cerebral vasodilating action of ATP were similar in the pattern to that of vasodilators such as papaverine hydrochloride.
对静脉注射1.0 - 3.0毫克/千克三磷酸腺苷对猫脑循环的影响以及对脑血管的舒张作用进行了研究。1. 正常颅内压组如先前报道，在最初30 - 100次检查时出现短暂低血压及其伴随的脑血液循环减少，随后在200 - 1000次检查时脑血流量增加。其增加的量和持续时间呈剂量依赖性。2. 颅内压负荷为20 - 30毫米汞柱的组（轻度升高组）与正常颅内压组一样出现脑血流量增加。然而，随着负荷压力升高，三磷酸腺苷的作用减弱或消失。3. 给药后立即观察到三磷酸腺苷的脑血管舒张作用，在影像学观察中其程度为30 - 50%。4. 三磷酸腺苷对脑血流量的增加作用和脑血管舒张作用在模式上与诸如盐酸罂粟碱等血管舒张剂相似。
