Nelson K E, Clayton R A, Gill S R, Gwinn M L, Dodson R J, Haft D H, Hickey E K, Peterson J D, Nelson W C, Ketchum K A, McDonald L, Utterback T R, Malek J A, Linher K D, Garrett M M, Stewart A M, Cotton M D, Pratt M S, Phillips C A, Richardson D, Heidelberg J, Sutton G G, Fleischmann R D, Eisen J A, White O, Salzberg S L, Smith H O, Venter J C, Fraser C M
Institute for Genomic Research, Rockville, Maryland 20850, USA.
Nature. 1999 May 27;399(6734):323-9. doi: 10.1038/20601.
The 1,860,725-base-pair genome of Thermotoga maritima MSB8 contains 1,877 predicted coding regions, 1,014 (54%) of which have functional assignments and 863 (46%) of which are of unknown function. Genome analysis reveals numerous pathways involved in degradation of sugars and plant polysaccharides, and 108 genes that have orthologues only in the genomes of other thermophilic Eubacteria and Archaea. Of the Eubacteria sequenced to date, T. maritima has the highest percentage (24%) of genes that are most similar to archaeal genes. Eighty-one archaeal-like genes are clustered in 15 regions of the T. maritima genome that range in size from 4 to 20 kilobases. Conservation of gene order between T. maritima and Archaea in many of the clustered regions suggests that lateral gene transfer may have occurred between thermophilic Eubacteria and Archaea.
海栖热袍菌MSB8的1860725碱基对基因组包含1877个预测的编码区域，其中1014个（54%）具有功能注释，863个（46%）功能未知。基因组分析揭示了许多参与糖类和植物多糖降解的途径，以及108个仅在其他嗜热真细菌和古菌基因组中有直系同源物的基因。在迄今测序的真细菌中，海栖热袍菌与古菌基因最相似的基因比例最高（24%）。81个类古菌基因聚集在海栖热袍菌基因组的15个区域，大小从4到20千碱基不等。在许多聚集区域中，海栖热袍菌和古菌之间基因顺序的保守性表明嗜热真细菌和古菌之间可能发生了横向基因转移。
