肝细胞癌中16号染色体长臂的缺失定位
Deletion mapping of chromosome 16q in hepatocellular carcinoma.
作者信息
Piao Z, Park C, Kim J J, Kim H
机构信息
Department of Pathology, Yonsei University, College of Medicine, Seoul, Korea.
出版信息
Br J Cancer. 1999 May;80(5-6):850-4. doi: 10.1038/sj.bjc.6690431.
Hepatocellular carcinoma (HCC) frequently shows an allelic imbalance (AI) on chromosome 16q. In order to define the commonly affected regions on chromosome 16q, we assessed AI studies in 41 HCCs using a panel of 37 microsatellite markers. Thirty-five cases (85%) showed AI at one or more loci. Among the 35 cases with AI, 21 cases showed multiple AI, suggesting the wide scope of deletion on the long arm of chromosome 16, and the remaining 14 cases showed partial AI. Detailed deletion mapping identified two independent commonly deleted regions on this chromosome arm. These included the D16S3106 locus and D16S498 locus. In conclusion, we have demonstrated frequent AI on 16q in HCCs and identified two loci with frequent AI, which may harbour new tumour suppressor genes.
肝细胞癌（HCC）常显示16号染色体上的等位基因不平衡（AI）。为了确定16号染色体上常见的受影响区域，我们使用一组37个微卫星标记评估了41例HCC中的AI研究。35例（85%）在一个或多个位点显示AI。在35例有AI的病例中，21例显示多个AI，提示16号染色体长臂上缺失范围广泛，其余14例显示部分AI。详细的缺失图谱确定了该染色体臂上两个独立的常见缺失区域。这些区域包括D16S3106位点和D16S498位点。总之，我们已经证明HCC中16q上频繁出现AI，并确定了两个频繁出现AI的位点，这可能包含新的肿瘤抑制基因。
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