Winell M, Holmberg B, Kronevi T
Environ Health Perspect. 1976 Oct;17:211-6. doi: 10.1289/ehp.7617211.
Plasma activities of alkaline phosphatase, (AP), transaminases and total lactate dehydrogenase (LDH) with isoenzymes were determined in mice inhaling 50 and 550 ppm vinyl chloride (VC). The animals were also autopsied and the tissue pathology was studies. The total LDH activity was elevanted in both dose groups along with a shift to cathodic enzymes. AP was increased in animals exposed to 500 ppm and transaminases were not at all changed. Enzyme changes occurred after the appearance of tumors. Alveologenic adenomas occurred in all animals at the higher dosage and in about half of the animals inhaling the lower dose. Subperitoneal and subcutaneous hemangiosarcomas were frequent in both dose groups; but especially among 50 ppm animals. Only one animal had a hemangiosarcoma of the liver. No liver fibrosis was seen. All primary subperitoneal and subcutaneous tumors were located in fat tissue. Telangiectasis was observed in two animals in the 500 ppm series. The importance of blood vessel changes in the toxicology of vinyl chloride is discussed.
对吸入50 ppm和550 ppm氯乙烯（VC）的小鼠，测定了其血浆碱性磷酸酶（AP）、转氨酶和总乳酸脱氢酶（LDH）及其同工酶的活性。对这些动物也进行了尸检，并研究了组织病理学。两个剂量组的总LDH活性均升高，同时向阴极酶转移。暴露于500 ppm的动物中AP升高，而转氨酶则完全没有变化。酶的变化在肿瘤出现后发生。高剂量组的所有动物以及吸入低剂量的约一半动物发生了肺泡性腺瘤。两个剂量组中腹膜下和皮下血管肉瘤都很常见；但在50 ppm组动物中尤其如此。只有一只动物患有肝血管肉瘤。未观察到肝纤维化。所有原发性腹膜下和皮下肿瘤均位于脂肪组织中。在500 ppm组的两只动物中观察到了毛细血管扩张。讨论了血管变化在氯乙烯毒理学中的重要性。
