急性川崎病患者中产生干扰素-γ（IFN-γ）的T细胞减少。
Decreased interferon-gamma (IFN-gamma)-producing T cells in patients with acute Kawasaki disease.
作者信息
Matsubara T, Katayama K, Matsuoka T, Fujiwara M, Koga M, Furukawa S
机构信息
Department of Paediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan.
出版信息
Clin Exp Immunol. 1999 Jun;116(3):554-7. doi: 10.1046/j.1365-2249.1999.00899.x.
Abstract
Kawasaki disease (KD) is an acute febrile illness of early childhood, in which the activation of monocytes/macrophages plays a central role in the development of vasculitis during the acute stage of disease. In this study we investigated peripheral blood T cells of 10 patients with KD, focusing on the Th1 and Th2 imbalance, using intracellular cytokine staining and analysis of the cytokine-producing T cells by flow cytometry. We observed a decrease in the numbers of IFN-gamma-producing, but not IL-4-producing, CD3+ T cells, during the acute stage. Our results suggest that there is an imbalance of Th1 and Th2 subsets during the acute stage of KD.
摘要
川崎病（KD）是一种幼儿期的急性发热性疾病，在疾病急性期，单核细胞/巨噬细胞的激活在血管炎的发展中起核心作用。在本研究中，我们使用细胞内细胞因子染色和流式细胞术分析产生细胞因子的T细胞，对10例川崎病患者的外周血T细胞进行了研究，重点关注Th1和Th2失衡情况。我们观察到，在急性期，产生IFN-γ的CD3 + T细胞数量减少，但产生IL-4的CD3 + T细胞数量未减少。我们的结果表明，川崎病急性期存在Th1和Th2亚群失衡。
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