Vikhliaev Iu I, Lando L I, Artemenko G N, Krupenina L B, Ul'ianova O V
Farmakol Toksikol. 1976 Jun-Aug;39(4):407-11.
Following introduction of triftazine (2 mg/kg) and phthoracizine 8 mg/kg, separately and in combination, the intensity of catalepsy, the content of dopamine, norepinephrine (fluorometrically), of acetylcholine (biologically) and the activity of cholinesterase (calorimetrically) in the caudate nuclei and the frontal part of the cortex were determined in rats. It was established that with its one-time administration phthoracizine, while keeping down the intensity of triftazine-induced catalepsy, prevents, at the same time, the development of a number of biochemical effects, viz. there appears a distinctly pronounced tendency toward mormalization of the dopamine, acetylcholine levels and of the cholinesterase activity. A multiple joint administration of the drugs is also attended by lowering the intensity of catalepsy. Then, biochemical changes manifest themselves in more complex interrelations.
分别单独及联合给予大鼠三氟拉嗪（2毫克/千克）和酞嗪（8毫克/千克）后，测定了大鼠尾状核和额叶皮质中僵住症的强度、多巴胺、去甲肾上腺素（荧光法）、乙酰胆碱（生物学法）的含量以及胆碱酯酶的活性（比色法）。结果表明，单次给予酞嗪时，在降低三氟拉嗪诱导的僵住症强度的同时，还能防止一些生化效应的发生，即多巴胺、乙酰胆碱水平和胆碱酯酶活性出现明显的正常化趋势。药物多次联合给药也会使僵住症强度降低。然后，生化变化表现为更复杂的相互关系。
