Nusbaum T J, Rose M R
Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA.
J Gerontol A Biol Sci Med Sci. 1999 May;54(5):B192-8. doi: 10.1093/gerona/54.5.b192.
There are parallels between the effects of laboratory selection and nutritional manipulation on the expression of lifespan and other fitness-related characters in Drosophila melanogaster. However, little is known about the effects of laboratory selection and nutritional manipulation when applied simultaneously. Given that D. melanogaster is one of the major model organisms for testing theories of aging, simultaneous application of laboratory selection and nutritional manipulation is of considerable interest. To that end we developed six groups of five fold replicated populations selected for either early or late fertility. Each of these groups was maintained on either high- or low-nutrition diets. Comparisons among the groups showed that nutrition is neutral in selecting for lifespan. Moreover, the dietary-restriction response can be broken by simultaneous selection and nutritional manipulation. Finally, characters that respond in a parallel manner under selection or nutritional manipulation may not when the two are applied simultaneously.
在实验室选择和营养调控对黑腹果蝇寿命及其他与适应性相关性状表达的影响之间存在相似之处。然而，对于同时应用实验室选择和营养调控的影响却知之甚少。鉴于黑腹果蝇是用于测试衰老理论的主要模式生物之一，同时应用实验室选择和营养调控具有相当大的研究价值。为此，我们构建了六组五重重复群体，分别针对早期或晚期生育力进行选择。这些组中的每一组都维持在高营养或低营养饮食条件下。组间比较表明，营养在选择寿命方面是中性的。此外，同时进行选择和营养调控可能会打破饮食限制反应。最后，在选择或营养调控下以平行方式做出反应的性状，在两者同时应用时可能并非如此。
