Rose M R, Vu L N, Park S U, Graves J L
Department of Ecology and Evolutionary Biology, School of Biological Sciences, University of California, Irvine 92717.
Exp Gerontol. 1992;27(2):241-50. doi: 10.1016/0531-5565(92)90048-5.
Tests for the causal involvement of specific physiological mechanisms in the control of aging require evidence that these mechanisms can be used to increase longevity or reproductive lifespan. Selection for later reproduction in Drosophila has been shown to lead to increased longevity, as well as increased resistance to starvation and desiccation stresses. Selection for increased resistance to starvation and desiccation in Drosophila melanogaster is here shown to lead to increased longevity, indicating that alleles that increase stress resistance also may increase longevity. The responses of desiccation and starvation resistance to selection are partly independent of each other, indicating a multiplicity of physiological mechanisms involved in selectively postponed aging, and thus aging in general.
检测特定生理机制在衰老控制中的因果关系，需要有证据表明这些机制可用于延长寿命或生殖寿命。在果蝇中选择较晚繁殖已被证明可延长寿命，并增强对饥饿和干燥胁迫的抵抗力。本文表明，在黑腹果蝇中选择增强对饥饿和干燥的抵抗力可延长寿命，这表明增强抗逆性的等位基因也可能延长寿命。干燥和饥饿抗性对选择的反应部分相互独立，这表明在选择性延缓衰老以及总体衰老过程中涉及多种生理机制。
