人疱疹病毒8特异性细胞毒性T细胞反应的鉴定
Identification of human herpesvirus 8-specific cytotoxic T-cell responses.
作者信息
Osman M, Kubo T, Gill J, Neipel F, Becker M, Smith G, Weiss R, Gazzard B, Boshoff C, Gotch F
机构信息
Departments of Oncology and Molecular Pathology, Royal Free and University College Medical School, University College London, London, United Kingdom.
出版信息
J Virol. 1999 Jul;73(7):6136-40. doi: 10.1128/JVI.73.7.6136-6140.1999.
Abstract
Human herpesvirus 8 (HHV-8) (or Kaposi's sarcoma-associated herpesvirus) is implicated in the etiopathogenesis of Kaposi's sarcoma (KS) and certain lymphoproliferations. The introduction of more effective therapies to treat human immunodeficiency virus infection has led to a decline in the incidence of KS and also in the resolution of KS in those already affected. This suggests that cellular immune responses including cytotoxic T lymphocytes (CTLs) could play a vital role in the control of HHV-8 infection and in KS pathogenesis. Here we elucidate HLA class I-restricted, HHV-8-specific cellular immune responses that could be important in the control of HHV-8 infection and subsequent tumor development. We show the presence of CTLs against HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in infected individuals.
摘要
人类疱疹病毒8型（HHV - 8）（或卡波西肉瘤相关疱疹病毒）与卡波西肉瘤（KS）的发病机制以及某些淋巴增殖性疾病有关。更有效的治疗人类免疫缺陷病毒感染的疗法的引入，导致了KS发病率的下降，也使已患病者的KS得到缓解。这表明包括细胞毒性T淋巴细胞（CTL）在内的细胞免疫反应可能在控制HHV - 8感染和KS发病机制中发挥至关重要的作用。在此，我们阐明了HLA I类限制性、HHV - 8特异性细胞免疫反应，这些反应可能在控制HHV - 8感染及随后的肿瘤发展中具有重要意义。我们发现感染个体中存在针对HHV - 8潜伏蛋白（K12）、裂解蛋白（K8.1）和高变蛋白（K1）的CTL。
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